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. 2022 Jan 31;13:828648. doi: 10.3389/fimmu.2022.828648

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Copyright © 2022 Mannino and Hart

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Depiction of the biosynthesis of UDP-GlcNAc and the effects conveyed on its substrates. UDP-GlcNAc is formed through the hexosamine biosynthetic pathway (HBP), combining several metabolites. O-GlcNAc cycling can modulate activity (CaMKII), stability (p53), and localization (NeuroD1) of its substrates.