TABLE 3.
Pharmacokinetic variables of total celiprolol in subjects with SLCO1A2 c.516A>C and ABCB1 haplotype‐based genotype scores <0.670 and ≥0.670
| Variable | Geometric mean (90% CI) | Geometric mean ratio (90% CI) | p value | |
|---|---|---|---|---|
| Genotype score <0.670; n = 27 | Genotype score ≥0.670; n = 168 | |||
| Cmax (ng/ml) | 347 (294, 408) | 686 (643, 732) | 0.51 (0.42, 0.60) | 1.07 × 10−9 |
| Tmax (h) a | 4 (0.5–5) | 4 (0.5–7) | 0.470 | |
| AUC0–∞ (ng·h/ml) | 1937 (1704, 2202) | 3548 (3370, 3733) | 0.55 (0.48, 0.63) | 1.08 × 10−11 |
| t ½ (h) | 4.8 (4.6, 5.0) | 4.5 (4.4, 4.6) | 1.07 (1.02, 1.12) | 0.013 |
The Cmax and AUC0–∞ data are adjusted for lean body weight and t ½ data for sex and estimated glomerular filtration rate.
Abbreviations: AUC0–∞, area under the plasma concentration‐time curve from 0 h to infinity; CI, confidence interval; Cmax, peak plasma concentration; Tmax concentration peak time; t ½, elimination half‐life.
a
Tmax is given as median with range.