TABLE 2.
Mean pharmacokinetic parameters of tolebrutinib part A (SAD)
| Dose, mg | Cmax, ng/ml | Tmax, h a | AUClast, ng.h/ml | AUC0‐inf, ng.h/ml | t 1/2, h |
|---|---|---|---|---|---|
| 5 (n = 6) | 0.369 (62%) | 1.0 (0.5–1.5) | 0.570 (84%) | 1.39 (n = 1) | 1.92 (87%) |
| 15 (n = 6) | 1.97 (51%) | 1.0 (1.0–1.0) | 3.67 (43%) | 4.06 (37%) | 1.39 (11%) |
| 30 (n = 6) | 3.12 (38%) | 1.0 (0.5–1.0) | 6.04 (29%) | 6.46 (27%) | 1.47 (25%) |
| 60 (n = 6) | 6.89 (57%) | 1.5 (1.0–1.5) | 15.6 (54%) | 15.9 (53%) | 1.67 (32%) |
| 120 (n = 6) | 32.3 (35%) | 1.0 (0.5–1.0) | 61.6 (54%) | 62.6 (54%) | 2.18 (32%) |
Abbreviations: AUC, area under the time‐concentration curve; Cmax, peak serum concentration after a single dose; SAD, single ascending dose; t 1/2, terminal half‐life; Tmax, time at which Cmax is obtained.
a
Median value (min – max).