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. 2022 Jan 31;12:818355. doi: 10.3389/fphar.2021.818355

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Copyright © 2022 Golshiri, Ataabadi, Jüttner, Snyder, Davis, Lin, Zhang, de Vries, Garrelds, Leijten, Danser and Roks.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endothelium-dependent and–independent responses and the contribution of NO and EDH pathways in isolated aortic rings (A,B) and the endothelium-dependent and–independent responses in mesenteric (C,D) rings from SMC-KO mice (open circles, bar) versus rings from SMC-LM (filled circles, bar) measured ex vivo in small wire organ baths. Relaxations are calculated relative to the contraction produced by U46619 30 mmol/L in each ring, which are set at 100%. Values are expressed as means ± SEM; n, number of mice; *, p < 0.05, GLM for repeated measures. #, p < 0.05, two-sided t-test.