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. 2022 Jan 31;8:835135. doi: 10.3389/fmolb.2021.835135

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Copyright © 2022 Zhou, Xu, Li, Ren, Chen, Xiong, Wang, Guo, Kang, Chen, Li, Yang, Zhang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MiRNAs and target genes validation. (A) Mind map for miRNAs and target genes screening. (B) RT-qPCR analysis to validate the expression of the selected miRNAs in ADSCs and Exo-ADSCs. (C) RT-qPCR analysis to validate the expression of the selected target genes in ADSCs and Exo-ADSCs. (D) The miRNA-gene-network based on the validated miRNAs and their target mRNAs. Green circular nodes represent the validated miRNAs, whose target mRNAs were validated by RT-qPCR. Blue square nodes represent their validated target mRNAs. The results were presented as the mean ± SD (n = 3 independent experiments). *p < 0.05, **p < 0.01, ***p < 0.001.