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Finding suitable therapeutic targets from genome-wide association studies with single-cell RNA sequencing. (A) UMAP visualization of 6191 cells divided into 18 cell populations derived from 38 human carotid artery plaques. (B) Heatmap of frequently studied coronary artery disease genome-wide association studies hits: EDN1, HDAC9, NOS3, VEGFA, FN1, APOE, APOB, SMAD3, PCSK9, and LDLR in atherosclerotic tissue shown in cells depicted in cell populations shown in A.
