Figure 2.

Genome-wide association studies candidate genes show cell-specific enrichment in atherosclerotic plaque cell populations. (A) Plot representing overlaps of genome-wide association studies candidate genes on cardiovascular disease with genes specifically expressed in cell populations from human atherosclerotic plaque. Colour intensity indicates enrichment over random data and size indicates adjusted P-value (Benjamini–Hochberg). (B) Genes for coronary artery disease underlying the overlaps in smooth muscle cell and ECI populations. Only significant overlaps are plotted. (C) Dotplot depicting expression of genes from B in the respective cell populations. (D) Average of normalized expression (zero mean across samples) of genes from coronary artery disease in smooth muscle cells from A in 30 tissues from GTEx.