Figure 4.

Analysis of three sub-populations of atherosclerotic smooth muscle cells. (A) UMAP visualisation of three sub-cell populations of smooth muscle cells in atherosclerotic plaque. (B) Dotplot depicting expression of synthetic and contractile smooth muscle cell markers in the three sub-populations. (C) Plot representing overlaps of genome-wide association studies candidate genes on cardiovascular disease and cardiometabolic traits with genes specifically expressed in the subset of smooth muscle cells from human atherosclerotic plaque. Colour intensity indicates enrichment over random data and size indicates adjusted P-value (Benjamini–Hochberg). (D) Plot depicting the number of unique and intersecting candidate genes from Large artery stroke enriched in transitional smooth muscle cells and synthetic smooth muscle cells.