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. 2022 Feb 14;14:8. doi: 10.1038/s41368-022-00160-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — The density of CD8⁺PD-1⁺TCF1⁻ terminally exhausted T cells (TCF1⁻Tex^term) indicated a favorable prognosis in head and neck squamous cell carcinoma (HNSCC) based on the density from mIHC results. a There was no significant overall survival (OS) analysis according to high and low densities of CD8⁺PD-1⁺TCF1⁺ progenitor exhausted T cells (TCF1⁺Tex^prog) in the SYSU cohort. b High density of TCF1⁻Tex^term predicted a better OS in the SYSU cohort. c There was no significant OS analysis according to high and low densities of TCF1⁺Tex^prog in the ZJU cohort. d High density of TCF1⁻Tex^term indicated a better OS in the ZJU cohort. The log-rank test was used for (a–d)