Figure 1:

(A) A rat being syringe-fed sucrose water during the training period. (B) The five-day training paradigm. The green arrows indicate compliance and red arrows indicated non-compliance. Rats that refuse the dose on first try are considered non-compliant for that day and then immediately offered the sweeter concentration of training solution from the previous day. Once successful, the training concentration for that day is re-offered. (C) The number of rats (n=13) that were compliance on their first attempt for each of the five days of training. By day five, all 13 are compliant with the drug delivery vehicle solution. The dotted line indicates the total number of rats in the cohort.