Figure 2.

Vector DNA and hOTCco mRNA analysis

Vector DNA and hOTCco mRNA were quantified in liver biopsies of individual cynomolgus macaques at day 28, day 84, and day 140. Vector DNA was measured by quantitative polymerase chain reaction (qPCR) and hOTCco mRNA by real-time qPCR. Vector DNA and hOTCco mRNA levels are shown by (A) day and (B and C) individual group. Data are represented as individual values for each animal with mean ± SEM. Statistical analysis was performed using a Friedman test with Dunn's multiple comparisons test for (A) and a Mann-Whitney test for (B and C). ns, not significant; ∗∗p = 0.0033; ∗∗∗p = 0.0001. F, female; GCs, genome copies; IS, immunosuppression; M, male. See also Figure S5.