Figure 5.

Analysis of hepatic IFN signature

The hepatic IFN gene signature was evaluated in individual cynomolgus macaques by determining the expression of 21 IFN-driven genes in liver lysates using a branched (b)DNA assay. (A) Hepatic IFN gene signature heatmaps show all 21 genes at day 28, day 84, and day 140. (B) Hepatic IFN gene signature by group at day 28 for the study animals alongside non-study control liver samples is shown. Data are represented as mean ± SEM of the median IFN signature bDNA signal normalized to expression of housekeeping for each animal. (C) Hepatic IFN gene signature at the indicated time points is shown. Data are represented as mean ± SEM of the median IFN signature bDNA signal for each group. Statistical analysis was performed using an unpaired t test. ∗∗p = 0.0023. ∗Animal BQ652 evaluated at day 103. See also Figure S9.