Table 1. Association between CD47, MCT1 or CD47-CD68 expression and various clinicopathological variables in breast cancer.
| Clinicopathological characteristics | N | CD47 | MCT1 | CD47-MCT1 | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| High expression (%) | χ2 | P | High expression (%) | χ2 | P | High expression (%) | χ2 | P | ||||
| Age (years) | 0.019 | 0.890 | 0.727 | 0.416 | 0.325 | 0.584 | ||||||
| <50 | 43 | 60.5% | 67.4% | 51.2% | ||||||||
| ≥50 | 94 | 61.7% | 74.5% | 56.4% | ||||||||
| Histological grade | 14.270 | ≤0.001* | 12.172 | 0.001* | 18.757 | ≤0.001* | ||||||
| G1–2 | 96 | 51.0% | 63.5% | 42.7% | ||||||||
| G3 | 41 | 85.4% | 92.7% | 82.9% | ||||||||
| TNM stage | 8.135 | 0.017* | 6.459 | 0.044* | 8.632 | 0.013* | ||||||
| I | 33 | 66.7% | 66.7% | 57.6% | ||||||||
| II | 60 | 48.3% | 65.0% | 41.7% | ||||||||
| III | 44 | 75.0% | 86.4% | 70.5% | ||||||||
| ER status | 0.157 | 0.706 | 0.029 | 1.000 | 0.462 | 0.573 | ||||||
| Negative | 41 | 63.4% | 73.2% | 58.5% | ||||||||
| Positive | 92 | 59.8% | 71.7% | 52.2% | ||||||||
| PR status | 0.016 | 1.000 | 0.068 | 0.848 | 0.332 | 0.605 | ||||||
| Negative | 64 | 62.5% | 73.4% | 57.8% | ||||||||
| Positive | 70 | 61.4% | 71.4% | 52.9% | ||||||||
| HER2 status | 0.155 | 0.817 | 0.026 | 1.000 | 0.045 | 1.000 | ||||||
| Negative | 109 | 62.4% | 72.5% | 56.0% | ||||||||
| Positive | 24 | 66.7% | 70.8% | 58.3% | ||||||||
| Lymph node metastasis | 1.252 | 0.278 | 2.295 | 0.165 | 2.444 | 0.153 | ||||||
| No | 66 | 57.6% | 70.2% | 48.5% | ||||||||
| Yes | 61 | 67.2% | 87.5% | 62.3% | ||||||||
| Death | 4.419 | 0.049* | 7.447 | 0.008* | 8.064 | 0.005* | ||||||
| No | 109 | 56.9% | 67.0% | 70.7% | ||||||||
| Yes | 28 | 78.6% | 92.9% | 78.6% | ||||||||
| Recurrence | 4.408 | 0.048* | 0.295 | 0.671 | 4.932 | 0.033* | ||||||
| No | 100 | 56.0% | 71.0% | 49.0% | ||||||||
| Yes | 37 | 75.7% | 75.7% | 70.3% | ||||||||
*, statistically significant. TNM, tumor node metastasis; ER, estrogen receptor; PR, progesterone receptor; HER2, human epidermal growth factor receptor 2; CD47, cluster of differentiation 47; MCT1, monocarboxylate transporter 1.