FIGURE 7.

Effects of bilateral EAAT2-S506X expression on the motor performance of Q175 mice. (A) Recordings of open field trajectories showing the mean running velocity between starts and stops (green or red circles, respectively). Gray level coding of instantaneous running velocity. (B) Motor activity at rest. Color coding of movement velocity at rest. (C,D,F–K) Quantification of results from open field testing. (E,F) Step-over latency – inverse relationship with number of starts in the open field, and sensitivity of step-over latency to mHTT and treatment. (L) Matched age-, CAG-, and body-weight composition of the test groups (only body weight illustrated). *p < 0.05, **p < 0.01, ***p < 0.001.