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. 2022 Jan 31;15:792652. doi: 10.3389/fncel.2021.792652

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Copyright © 2022 Hirschberg, Dvorzhak, Rasooli-Nejad, Angelov, Kirchner, Mertins, Lättig-Tünnemann, Harms, Schmitz and Grantyn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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No recovery of astrocytic glutamate uptake and motor performance in mice overexpressing the full-length form of EAAT2. (A) Injected vectors. (B) Animal groups. The injected animals were matched for age, body-weight and the number of CAG-repeats. The numbers refer to the experiments with SBFI imaging. (C) Measurement of single-cell glutamate uptake by sodium imaging with SBFI. Same conditions as in Figure 5. Averaged traces from mRuby3+ astrocytes only. (D) Quantification of results with two-level (“nested”) ANOVA statistics (animal level and cell level) and two-level post hoc tests for the differences between the test groups. (E–I) Lack of recovery from the signs of hypokinesia. Here as in all other figures: n.s., not significant. *p < 0.05.