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. 2022 Jan 31;8:826687. doi: 10.3389/fcvm.2021.826687

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Copyright © 2022 Quiroz, Valencia, Shao, Li, Ortiz, Parikh, Lassance-Soares, Vazquez-Padron, Liu and Velazquez.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MSC^{E−selectin−GFP} treatment increases ischemic limb reperfusion. (A) The quantitative analysis of limb reperfusion measured by LDI (reperfusion index % = ischemic ligated footpad/normal control footpad, mean ± SD; **P < 0.01 by ANOVA and *P < 0.05 by post-hoc analysis, Vehicle n = 6, MSC^GFP n = 20, MSC^{E−selectin−GFP} n = 18). (B) Representative images of hindlimb reperfusion by LDI obtained preoperatively, immediately after FAL (postoperative), and on postoperative days (POD) 7, 14, and 21.