Table 1.
Genes upregulated in E-selectin supercharged mesenchymal stem cells (MSCs) (compared to MSCGFP) and their previously described functions.
| Symbol | Gene name | GenBank | Function |
|---|---|---|---|
| Tbx1† | T-box 1 | NM_011532 | Controls vascular smooth muscle and extracellular matrix investment in great vessel remodeling (39) |
| Lep† | Leptin | NM_008493 | Regulates energy homeostasis (40) |
| IL6 | Interleukin-6 | NM_031168 | Mediates the immune system and regenerative processes (41) |
| Ilb1 | Interleukin-1β | NM_008361 | Mediates inflammation and lymphocyte activation (42) |
| Flt1 | Fms Related Receptor Tyrosine Kinase 1 | NM_010228 | Acts as a cell-surface receptor for VEGFA, VEGFB, and PGF and regulates cell migration along with post-natal angiogenesis (43–45) |
| F2† | Coagulation Factor II | NM_010168 | Involved in blood homeostasis and wound healing (46) |
| Cxlc2† | Chemokine (C-X-C motif) ligand 2 | NM_009140 | Plays a role in improved cellular trafficking and engraftment (47) |
| Ccl11 | C-C Motif Chemokine Ligand 11 | NM_011330 | Promotes accumulation of eosinophils (48) |
| Angpt1† | Angiopoietin 1 | NM_009640 | Promotes endothelial cell survival for angiogenesis (49) |
Table listing full name of upregulated genes with the † mark indicating the genes also upregulated in vivo within the ischemic tissue injected with supercharged MSCE−selectin−GFP vs. the ischemic tissue injected with control MSCGFP.
VEGFA, vascular endothelial growth factor a; VEGFB, vascular endothelial growth factor B; PGF, placental growth factor.