Table 1.

Overview of genotypic and phenotypic data of related members in this pedigree.

Individual	Gender	Age	Age at onset*	Renal function	Renal Biopsy#	Gene variants&	WES
III-5	Male	72	NA	Normal	NA	NA	Yes
III-6	Female	73	50/proteinuria/ hematuria	Normal	NA	WT1: exon9: c.1397C>T;p.Ser466Phe	Yes
						NPHS1: exon27: c.3478C>T;p.Arg1160Ter
III-7	Male	71	NA	Normal	NA	NPHS1: exon27: c.3478C>T;p.Arg1160Ter	No
III-8	Female	70	NA	Normal	NA	NA	No
IV-4	Male	42	NA	Normal	NA	NA	No
IV-5	Male	52	32/proteinuria	Normal	IgAN	WT1: exon9: c.1397C>T;p.Ser466Phe	Yes
						NPHS1: exon27: c.3478C>T;p.Arg1160Ter
IV-6	Female	54	NA	Normal	NA	NA	Yes
IV-7	Male	50	30/proteinuria/hematuria	ESKD	NA	WT1: exon9: c.1397C>T;p.Ser466Phe	Yes
IV-8	Female	49	NA	Normal	NA	WT1: exon10: c.1433-10G>A	Yes
IV-9	Male	45	NA	Normal	NA	NA	No
IV-10	Male	42	NA	Normal	NA	NA	No
V-1	Male	31	18/proteinuria	Normal	NA	WT1: exon9: c.1397C>T;p.Ser466Phe	Yes
V-2	Female	30	NA	Normal	NA	NA	No
V-3	Male	29	NA	Normal	NA	NPHS1: exon27: c.3478C>T;p.Arg1160Ter	Yes
V-4	Female	27	NA	Normal	NA	NA	No
V-6	Female	28	24/proteinuria/hematuria	ESKD	IgAN	WT1: exon9: c.1397C>T;p.Ser466Phe	Yes
						WT1: exon10: c.1433-10G>A
V-7	Male	24	15/proteinuria/hematuria	ESKD	NA	WT1: exon9: c.1397C>T;p.Ser466Phe	Yes
						WT1: exon10: c.1433-10G>A
VI-1	Female	4	NA	Normal	NA	WT1: exon9: c.1397C>T;p.Ser466Phe	No
VI-2	Female	5	NA	Normal	NA	NPHS1: exon27: c.3478C>T;p.Arg1160Ter	No

WES, whole-exome sequencing; WT1, Wilms tumor suppressor 1; NPHS1, nephrin; IgAN, IgA nephropathy; ESKD, end-stage kidney disease.

^*NA means renal function was normal so far.

^#NA means family members did not take renal biopsy.

^&NA means no gene variant was detected.