Figure 3.

The progress in peptide-based vaccines for TB. The PubMed database was used to search the literature related to the peptide-based vaccine for TB using “peptide, epitope, and tuberculosis”. Their relationships were shown as bubble charts based on publication year and association strength by using VOSviewer software (A). Furthermore, the relationships among 150 pieces of literature related to peptides or epitopes for TB were shown by using Gephi software. These literatures were divided into four categories: epitope screening and prediction, vaccine construction, immunogenicity, and protective efficacy. Gephi software was used to show 150 articles under corresponding authors. Each bubble represents a study, the size of which is proportional to the number of papers the author has published, and the color from blue to purple indicates the level of activity (B).