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. 2022 Jan 31;13:825428. doi: 10.3389/fimmu.2022.825428

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Copyright © 2022 Wang, Shi, An, Li, Bai, Wu, Shen, Du, Cheng, Wu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEITC prevented hepatocyte pyroptosis induced by ConA. (A) Immunoblot analysis of NLRP3, pro-CASP1, cleaved CASP1, GSDMD, GSDMD-N, and β-actin in liver tissues of mice induced by ConA (0, 4, 8, 12, and 16 h). (B) The relative protein levels of NLRP3/β-actin, cleaved CASP1/pro-CASP1, and GSDMD-N/GSDMD are displayed as histograms. (C) The expression levels of serum IL-1β. (D, E) Western blot and statistical analysis of NLRP3, pro-CASP1, cleaved CASP1, GSDMD, GSDMD-N, and β-actin. Data are presented as the means ± SEM (n = 6–10 per group). ^#p < 0.05 vs. normal group, ^*p < 0.05, ^**p < 0.01 vs. ConA control.