Figure 5.

PEITC ameliorated the acute chemical liver injury model and hepatocyte pyroptosis induced by CCl₄ in mice. (A) Schematic overview of the CCl₄-induced acute chemical liver injury model. (B) The lesions on the surface of liver tissues were photographed. (C) H&E staining of liver tissue sections. Scale bar, 200 µm. (D–F) The levels of serum LDH, ALT, and AST. (G) Western blot analysis of NLRP3, pro-CASP1, cleaved CASP1, GSDMD, GSDMD-N, and β-actin. Data are presented as the means ± SEM (n = 6–10 per group). ^###p < 0.001 vs. normal group, ^*p < 0.05, ^***p < 0.001 vs. CCl₄ control.