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. 2022 Jan 31;13:825428. doi: 10.3389/fimmu.2022.825428

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Copyright © 2022 Wang, Shi, An, Li, Bai, Wu, Shen, Du, Cheng, Wu and Xu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PEITC directly inhibited GSDMD by interacting with cysteine 191 of GSDMD. (A) The effect of PEITC on the thermal stability of mouse GSDMD was detected by CETSA, and the line graph was used to show the remaining GSDMD amount at different temperatures. (B) The binding ability between PEITC and mouse GSDMD was detected by MST. (C) The secretion levels of LDH in cell culture supernatants. (D) The effect of PEITC and NSA on the thermal stability of human GSDMD WT. (E) The binding ability between human GSDMD WT and PEITC or NSA. (F) The effect of PEITC and NSA on the thermal stability of human GSDMD C191A. (G) The binding ability between human GSDMD C191A and PEITC or NSA. Data are presented as means ± SEM. ^#p < 0.05, ^##p < 0.01, ^###p < 0.001 vs. DMSO or blank, ^*p < 0.05, ^**p < 0.01 vs. GSDMD WT control.