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Treatment of B6D2F1 with anti-TNFα antibody results in progressive Coccidioides disease. B6D2F1 mice were treated with 500 μg isotype control (black line) or anti-TNFα antibody (red line) starting on day -2 before infection; dosing was continued on an alternating q3/4d schedule. An additional cohort of controls was treated with dexamethasone in their drinking water (purple line). On day 0, mice were infected with ~50 arthroconidia of Cp1038 and followed for disease progression.
