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. 2022 Jan 31;13:824967. doi: 10.3389/fmicb.2022.824967

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Copyright © 2022 Caniego-Casas, Martínez-García, Alonso-Riaño, Pizarro, Carretero-Barrio, Martínez-de-Castro, Ruz-Caracuel, de Pablo, Saiz, Royo, Santiago, Rosas, Rodríguez-Peralto, Pérez-Mies, Galán and Palacios.

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(A) Hematoxylin and eosin. Ciliated bronchial epithelial cells with amphophilic nuclear inclusions (arrowheads). Scale bar: 100 μm. (B) Polyomavirus BK immunohistochemistry. Same area as panel (A), showing positive staining in the nuclear inclusions (arrowheads). Scale bar: 100 μm. (C) Electron micrograph of an infected cell containing intranuclear inclusions (between asterisks). Scale bar: 2 μm. (D) Intranuclear icosahedral inclusions. Scale bar: 1 μm. Inset: Note the 40 nm particles characteristic of the polyoma virus group. Scale bar: 200 nm.