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. 2022 Jan 31;13:830710. doi: 10.3389/fimmu.2022.830710

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Copyright © 2022 Maciola, La Raja, Pacenti, Salata, De Silvestro, Rosato and Pasqual

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Spike IgG antibodies generated after natural COVID-19 infection are not polarized toward the receptor-binding domain (RBD) region. (A) Correlation between Spike IgG titer and RBD IgG titers across all patients from our cohort. The red solid line indicates the mean RBD/Spike titer ratio (1.7), while the two dotted lines indicate the SD ( ± 1.2). (B) Spike and RBD IgG titration (mean ± SD) by ELISA across 9 serial dilutions of the anti-RBD monoclonal Ab CR3022. (C) Ratio between RBD and Spike IgG titers across all patients in the cohort. Results are in box-and-whiskers plot (Tukey) indicating cohort distribution (right panel, only individual data outside from the whiskers are displayed with a symbol). The red line indicates the RBD/Spike titer ratio relative to CR3022 mAb (3.3).