Table 2.

Epigenetic drugs that modulate ferroptosis in cancer therapy.

Drug type	Name	Molecular mechanism	Consequence on ferroptosis	Cancer types	Reference
DNMT inhibitors	5-Aza-cd	Inhibition of DNMT by 5-Aza-cd increases the expression of E-cadherin and GPX4	Inhibition	Head and neck cancer	(51, 52)
BET inhibitors	JQ-1	Inhibition of BRD4 by JQ-1 downregulates the expression of GPX4, SLC7A11 and SLCA2	Promotion	Breast cancer; Lung Adenocarcinoma	(57)
HDAC inhibitors	EX-527	Inhibition of SIRT1 by EX-527 increases EMT	Promotion	Head and neck cancer	(51)
	Vorinostat	Unknown	Promotion	Small cell lung cancer; IDH1/2 mutant brain tumors	(84)