Figure 10.

Comparison of the samples comprising the top PGS quantiles for the PNC AFR cohort

(A) The samples located at the top 20%, 10%, and 5% of the PTSD PGS distribution were virtually the same when PGS were computed twice using the same discovery GWAS. For example, 644 out of the 652 samples (98.7%) at or above the 80th percentile were the same between the two batches of PGS. (B) The overlap between samples at all three quantiles dropped substantially when the PGS computed from the AFR PGC Freeze 1 PTSD discovery GWAS³⁸ were compared with those computed from the AFR Freeze 2 PTSD discovery GWAS (Nievergelt et al.³⁹), with the degree of overlap being reduced at higher quantiles. (C) The degree of overlap was further reduced when comparing PGS computed from an AFR-ancestry discovery GWAS to those computed from a EUR-ancestry GWAS for PTSD (Nievergelt et al.³⁹), T2D,^41,42 and height (Marouli et al.⁴⁴). For context, the green bars depict the number of samples included at or above the 80th percentile (n = 652), 90th percentile (n = 326), and 95th percentile (n = 163). Additional results can be found in Tables S10 and S11.