Figure 11.
Comparison of the samples comprising the top PGS quantiles for the PNC EUR cohort
(A) The EUR samples located within the top 20%, 10%, and 5% of the PTSD PGS distribution were nearly the same when PGS were computed twice using the same EUR discovery GWAS (Nievergelt et al.39). For example, 1,026 out of the 1,048 samples (97.9%) at or above the 80th percentile were the same between the two runs of PRS-CS. (B) The overlap between samples at all three quantiles dropped substantially when the PGS computed from two different EUR discovery GWAS were compared for PTSD,38,39 T2D,40,41 and height.43,44 (C) The degree of overlap was dramatically reduced when comparing PGS computed from an AFR-ancestry discovery GWAS with those computed from an EUR-ancestry GWAS for PTSD (Nievergelt et al.39), T2D,41,42 and height.43,44 Green bars depict the number of samples included at or above the 80th percentile (n = 1,048), 90th percentile (n = 524), and 95th percentile (n = 262). Additional results can be found in Tables S12 and S13.