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. 2022 Jan 31;8:810477. doi: 10.3389/fcvm.2021.810477

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Copyright © 2022 Ye, Fu, Chung, Cao, Ko, Tian, Tang and Lui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Endothelial agrin is dispensable for endothelium dependent vasoreactivity in vivo. (A–F) Concentration dependent vasoreactivity measured in the (A–D) aorta and (E–H) femoral artery of 6-8 weeks old EC-agrn^+/+ and EC-agrn^cKO mice, respectively, showing no significant difference after endothelial loss of agrin. (A,E) Concentration dependent vasocontractions of mouse aorta or femoral artery of the limb in response to phenylephrine (Phe) were measured. (B,F) Dose response curve showing EC50 of Phe-induced vasocontractions. (C,G) Concentration dependent EDRs of mouse aorta or femoral artery of the limb in response to acetylcholine (Ach) were measured. (D,H) Reactions were antagonized by co-treatment with NOS inhibitor, L-NAME. (A–H) Data are presented as mean ± S.E.M., n = 5–6, differences were determined by ANOVA and Turkey's HSD post-hoc test, n.s. denotes no significant difference.