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. 2022 Jan 31;8:810477. doi: 10.3389/fcvm.2021.810477

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Copyright © 2022 Ye, Fu, Chung, Cao, Ko, Tian, Tang and Lui.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Agrin does not regulate endothelial YAP mediated activation in vivo. (A) Western blotting analysis showing no significant difference in the nuclear or cytoplasmic distributions of Yap but significantly reduced Taz after endothelial loss of agrin in vivo. The nuclear and cytoplasmic (B,C) expression and (D,E) activation levels of YAP; as well as the (F) nuclear and (G) cytoplasmic expression levels of Taz were measured in the skeletal muscle ECs of 6–8 weeks old EC-agrn^+/+ and EC-agrn^cKO mice, respectively. (H) RT-qPCR analysis showing no significant difference in expression levels of YAP target genes after endothelial loss of agrin. (B–H) Data are presented as mean ± S.E.M., n = 3-6, differences were determined by ANOVA and Turkey's HSD post-hoc test, *P < 0.05, **P < 0.01, ***P < 0.001, n.s. denotes no significant difference.