Table 2.
Clinical and treatment related of HIV-positive children on antiretroviral therapy at University of Gondar Compressive Specialized Hospital in Northwest Ethiopia, from January 2005 to December 2018 (n = 344).
| Variables | Frequency (n = 344) | Percent (%) |
|---|---|---|
| Baseline WHO clinical stage | ||
| Stages 1 and 2 | 255 | 74.1 |
| Stages 3 and 4 | 89 | 25.9 |
| Baseline CD4 count | ||
| Below threshold | 55 | 16.0 |
| Above threshold | 289 | 84.0 |
| Disclosure status | ||
| Disclosed | 167 | 48.5 |
| Non-disclosed | 177 | 51.5 |
| ART adherence | ||
| Good | 267 | 77.6 |
| Fair and poor | 77 | 22.4 |
| Initial regiment change | ||
| Yes | 78 | 22.7 |
| No | 266 | 77.3 |
| Reason for regiment change | ||
| Side effect/toxicities | 32 | 9.3 |
| Stock out | 12 | 3.5 |
| Treatment failure | 34 | 9.9 |
| Treatment failure | ||
| Yes | 34 | 9.9 |
| No | 310 | 90.1 |
| Immunologic failure | ||
| Yes | 9 | 2.6 |
| No | 335 | 97.4 |
| Clinical failure | ||
| Yes | 12 | 3.5 |
| No | 332 | 96.5 |
| Both immunologic failure and clinical failure | ||
| Yes | 6 | 1.7 |
| No | 338 | 98.3 |
| Virological failure | ||
| Yes | 7 | 2.0 |
| No | 337 | 98.0 |
| Baseline hemoglobin level | ||
| ⩽10 mg/dL | 43 | 12.5 |
| >10 mg/dL | 301 | 87.5 |
| Baseline height for age | ||
| Stunting | 141 | 41.0 |
| Normal | 203 | 59.0 |
| Baseline weight for age | ||
| Underweight | 176 | 51.2 |
| Normal | 168 | 48.8 |
| Baseline functional status >5 years (n = 248) | ||
| Working | 226 | 91.1 |
| Ambulatory | 19 | 7.7 |
| Bedridden | 3 | 1.2 |
| Baseline development status ⩽5 years (n = 96) | ||
| Appropriate | 85 | 88.6 |
| Delayed | 8 | 8.3 |
| Regressed | 3 | 3.1 |
| Timing of initiation | ||
| Early (⩽6 months) | 212 | 61.6 |
| Late (>6 months) | 132 | 38.4 |
| Year of initiations | ||
| ⩽2013 | 215 | 62.5 |
| ⩾2014 | 129 | 37.5 |
| Presence of TB | ||
| Yes | 37 | 10.8 |
| No | 307 | 89.2 |
| OI other than TB | ||
| Yes | 113 | 32.8 |
| No | 231 | 67.2 |
| CPT | ||
| Yes | 301 | 87.5 |
| No | 43 | 12.5 |
| IPT | ||
| Yes | 105 | 30.5 |
| No | 339 | 69.5 |
| Initial ART regiment-based | ||
| PI (protease inhibitor)-based | 28 | 8.1 |
| NVP/EVZ-based | 316 | 91.6 |
| Duration on ART | ||
| <12 months | 35 | 10.2 |
| 12 months to 60 months | 161 | 46.8 |
| >60 months | 148 | 43.0 |
NVP: nevirapine; EVZ: efavirenz; ART: antiretroviral therapy; OI: opportunistic infection; TB: tuberculosis; WHO: World Health Organization; CPT: cotrimoxazole prophylactic therapy; IPT: isoniazid prophylactic therapy; CD4: cluster of differentiation 4.