Table 1.
Only male study participants anthropometric, biochemical and liver-specific characteristics (mean (± SD) or median (25thto 75th percentile) data) according to five different alcohol intake groups in the main manuscript.
| Variable | Groups of total alcohol consumption |
||||||
|---|---|---|---|---|---|---|---|
| Male | No intake 0 g/d ethanol |
Low intake > 0 - 37.5 g/d ethanol |
Medium intake > 37.5 - 50.0 g/d ethanol |
High intake > 50 - 100 g/d ethanol |
Very high intake > 100 g/d ethanol |
Pa | FDR-Pb |
| N | 705 | 1083 | 302 | 184 | 36 | - | - |
| Age (years) | 61 ± 11.2 | 62.4 ± 10.7 | 62 ± 10.1 | 61.2 ± 8.78 | 57.9 ± 10.1 | 0.009 | 0.020 |
| BMI (kg/m2) | 27.6 ± 4.2 | 27.5 ± 3.61 | 27.5 ± 3.37 | 28.1 ± 3.86 | 27.8 ± 3.85 | 0.347 | 0.440 |
| LDL-cholesterol (mg/dl) | 113.0 ± 33.6 | 113.0 ± 31.6 | 113.0 ± 33.6 | 115.0 ± 32.9 | 121.0 ± 33.4 | 0.636 | 0.711 |
| HDL-cholesterol (mg/dl) | 34.6 ± 9.2 | 37.0 ± 9.56 | 39.2 ± 10.1 | 38.6 ± 10.7 | 40.0 ± 11.1 | <0.001 | <0.001 |
| Apolipoprotein A-I (mg/dl) | 119.0 ± 21.1 | 125.0 ± 22.0 | 130.0 ± 23.0 | 130.0 ± 24.9 | 132.0 ± 28.3 | <0.001 | <0.001 |
| Apolipoprotein A-II (mg/dl) | 38.9 ± 8.46 | 41.3 ± 9.31 | 43.2 ± 9.71 | 44.2 ± 10.0 | 43.7 ± 13.9 | <0.001 | <0.001 |
| Triglycerides (mg/dl) | 155 (111-202) | 146 (108-196) | 148 (115-198) | 158 (112-224) | 130 (92.8-202) | 0.046 | 0.072 |
| Fasting glucose (mg/dl) | 102 (93.6-121) | 103 (93.6-118) | 104 (96.8-116) | 105 (97.1-119) | 107 (98.1-116) | 0.446 | 0.529 |
| HbA1c (%) | 6.45 ± 1.36 | 6.17 ± 1.18 | 6.24 ± 1.03 | 6.23 ± 1.11 | 6.24 ± 1.04 | <0.001 | <0.001 |
| Systolic blood pressure (mmHg) | 140.0 ± 24.2 | 142.0 ± 22.9 | 140 ± 22.2 | 141 ± 22.6 | 136 ± 23.7 | 0.239 | 0.325 |
| Diastolic blood pressure (mmHg) | 80.9 ± 11.7 | 82.4 ± 11.6 | 81.1 ± 10.7 | 81.5 ± 10.7 | 78.4 ± 9.16 | 0.026 | 0.049 |
| eGFR (ml/min/1.73 m2) | 82.5 ± 21.8 | 83.8 ± 19.4 | 85.3 ± 18.3 | 85.8 ± 18.4 | 96.2 ± 15.3 | <0.001 | 0.001 |
| hsCRP (mg/L) | 3.6 (1.57-8.85) | 2.83 (1.1-7.59) | 3.22 (1.24-9.07) | 4.88 (1.56-9.27) | 7.39 (2.04-19.1) | <0.001 | <0.001 |
| NT-pro-BNP (pg/mL) | 302 (100-876) | 282 (97-835) | 289 (97-881) | 278 (101-881) | 374 (142-933) | 0.822 | 0.822 |
| Coronary artery disease (%) | 86.8 | 82.7 | 83.1 | 78.8 | 77.8 | 0.042 | 0.072 |
| Hypertension (%) | 72.2 | 71.2 | 70.9 | 71.2 | 61.1 | 0.710 | 0.749 |
| Diabetes mellitus type 2 (%) | 44.3 | 38.3 | 36.4 | 38.6 | 44.4 | 0.070 | 0.103 |
| Smoking (pack years) | 17.5 (1-37.5) | 12.5 (0.15-32) | 16.5 (3.1-33.4) | 22.5 (5.75-45) | 22.0 (9.38-34.6) | 0.005 | 0.012 |
| Smoking (active/former/ never (%)) | 29.4/47.5/23.1 | 21.7/53.4/24.9 | 27.2/52/20.9 | 35.9/46.2/17.9 | 41.7/41.7/16.7 | <0.001 | 0.001 |
| Alanine aminotransferase (U/L) | 10.0 (8.0-13.0) | 10.0 (8.0-13.0) | 11.0 (9.0-14.0) | 12.0 (9.0-16.0) | 11.0 (9.75-16.0) | 0.001 | 0.001 |
| Aspartate aminotransferase (U/L) | 13.0 (10.0-20.0) | 14.0 (10.0-21.0) | 14.0 (10.0-20.0) | 15.0 (11.0-24.0) | 14.0 (10.8-17.0) | 0.034 | 0.050 |
| De Ritis ratio | 1.35 (1.07-1.72) | 1.33 (1.07-1.69) | 1.32 (1.08-1.67) | 1.33 (1.11-1.6) | 1.24(0.93-1.55) | 0.473 | 0.473 |
| γ-Glutamyltransferase (mg/dl) | 17.0 (11.0-28.0) | 19.0 (12.0-30.0) | 21.0 (13.0-37.8) | 28.0 (17.0-51.2) | 40.0 (22.2-63.0) | <0.001 | <0.001 |
| Mean corpuscular volume (fL) | 88.6 (85.9-91.4) | 89.3 (86.5-92.3) | 89.8 (87.0-92.1) | 91.4 (88.1-94.2) | 91.5 (87.5-95.4) | <0.001 | <0.001 |
| Fibrinogen (mg/L) | 386 (325-465) | 365 (311-444) | 378 (321-464) | 398 (333-453) | 408 (337-496) | 0.003 | 0.006 |
| Fatty liver index | 55.2 (34.2-76.6) | 55.5 (35.3-76.8) | 62.3 (39.5-78.5) | 72.2 (48.3-86.5) | 75.1 (36.8-87.9) | <0.001 | <0.001 |
| Interleukin 6 (ng/L) | 3.39 (1.89-6.81) | 3.09 (1.78-5.6) | 3.21 (1.92-6.17) | 4.04 (2-7.59) | 3.32 (1.9-10.6) | 0.008 | 0.015 |
| Mean platelet volume (fL) | 8.9 (8.3-9.6) | 8.9 (8.3-9.6) | 8.9 (8.33-9.6) | 9.2 (8.4-9.9) | 8.95 (8.38-9.52) | 0.107 | 0.123 |
a
ANOVA (non-normally distributed variables were analysed by Kruskal-Wallis rank sum test) or Chi square test.
b
p-Value after FDR correction.