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Reagents and conditions: (a) dimethylphosphine oxide, Pd(OAc)2, xantphos, K3PO4, DMF, 120 °C, overnight, 82%; (b) R1 substituted pyrimidine, K2CO3, n-Bu4NHSO4, DMF, 65 °C, overnight, 63–84%; (c) R2 substituted aniline, 2.5 M HCl in EtOH, 2-methoxyethanol, 120 °C, overnight, 37–75%.
