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. 2022 Jan 7;13(2):196–202. doi: 10.1021/acsmedchemlett.1c00555

Table 3. Mean PK Parameters of 18f and 18k after po or iv Administration in SD Ratsa.

  18f
 18k
parameters pob ivc pob ivc
T1/2 (h) 2.84 ± 0.11 3.73 ± 1.36 2.16 ± 0.2 2.67 ± 0.45
Tmax (h) 1.50 ± 0.87   2.67 ± 1.15  
Cmax (ng/mL) 470 ± 155 345 ± 52 868 ± 181 288 ± 16
AUC(0-t) (h·ng/mL) 2553 ± 704 862 ± 88 4552 ± 1154 929 ± 91
AUC(0-∞) (h·ng/mL) 2563 ± 709 898 ± 57 5219 ± 1536 1060 ± 144
CL (mL/min/kg)   9.30 ± 0.57   7.97 ± 1.17
MRT(0-∞) (h) 4.79 ± 0.49 4.08 ± 1.24 4.37 ± 0.62 3.65 ± 0.56
Vss (mL/kg)   2275 ± 710   1720 ± 40
F (%) 49.3 ± 11.8   81.7 ± 20.7  
a

n = Three animals per study.

b

Dosed at 3 mg/kg.

c

Dosed at 0.5 mg/kg.