TABLE 2.

Frequency of mutations in RMP-resistant M. tuberculosis isolates from different geographic regions

Mutated codon(s)	% Mutations in geographic region:
	Africaa (reference 22; n = 105)	Asiab (reference 8; n = 77)	Australia (reference 31; n = 33)	Brazilc (reference 27; n = 82)	Germanyd (reference 20; n = 36)	Greecee (reference 13; n = 17)	Italy (reference 18; n = 37)	United States (reference 30; n = 61)	Hungaryf(n = 29)
572			3.0
533	3.0			1.2				3.3
531	53.5	46.8	48.5	53.7	36.1	47.1	56.7	34.4	31.0
526	21.2	18.2	30.3	20.6	22.2	17.7	29.7	39.3	6.8
522	10g	1.3	6.1	2.4				1.6
521								1.6
518	1.0							1.6
516	13.1	16.9	9.1	7.4	2.8	5.9	2.7	6.6	37.9
514		2.6						1.6
513	3.0	6.5		1.2					6.8
511	2.0	1.3		1.2
508						17.7
505						5.9
504	2.0
531 and 526				1.2	2.8	5.9	2.7
No mutation	14.1	6.5	3.0	3.7	33.3			8.2	10.3h

^aSouth Africa (n = 87), Sierra Leone and Uganda (n = 16), and Namibia (n = 2). 

^bBangladesh (n = 2), India (n = 4), Indonesia (n = 1), Malaysia (n = 14), Myanmar (n = 15), Nepal (n = 2), the Philippines (n = 4), Thailand (n = 14), and Yemen (n = 21). 

^cLess common mutations (1.2% each) were as follows: 531 and 514; 516 and 511; 515 and 511; 526 and 531; 524, 525, and 526 and deletion 527; deletion 515, 516, 517, and 518; 513 and deletion 514, 515, and 516. 

^dA rare (2.8%) double mutation was detected at codons 526 and 511. 

^eRare (2.7% each) triple mutations were detected at codons 553, 541, and 526; 525, 523, and 516; and 516, 512, and 511. 

^fA deletion (522–525) that has not been reported previously was detected in one strain (3.4%). 

^gSilent mutation. 

^hIn one of these three strains, an N-terminal V146F mutation was detected.