Table 2.
Geometric mean titers by adverse reaction variables for each dose.
| Dose 1 |
Dose 2 |
||||||
|---|---|---|---|---|---|---|---|
| No. (%) | GMT (95 %CI) | p-value | No. (%) | GMT (95 %CI) | p-value | ||
| Use of antipyretic Medications | |||||||
| Use of Antipyretic Medications after Vaccination | No | 293 (87.5) | 8,922 (8,243–9,658) | 0.373a | 191 (57.0) | 8,163 (7,384–9,026) | 0.017a |
| Yes | 42 (12.5) | 8,084 (6,574–9,940) | 144 (43.0) | 9,757 (8,766–10,857) | |||
| Local Reactions | |||||||
| Pain at inInjection site | No | 116 (49.4) | 8,728 (7,674–9,924) | 0.400a | 131 (55.7) | 8,993 (7,998–10,113) | 0.840a |
| Yes | 119 (50.6) | 9,406 (8,343–10,605) | 104 (44.3) | 9,154 (8,015–10,457) | |||
| Redness | No | 233 (99.2) | 9,014 (8,257–9,840) | 0.318a | 222 (94.5) | 9,034 (8,243–9,901) | 0.763a |
| Yes | 2 (0.9) | 17,742 (161–811,757) | 13 (5.5) | 9,581 (7,470–12,286) | |||
| Swelling | No | 225 (95.7) | 9,135 (8,362–9,979) | 0.517a | 218 (92.8) | 9,009 (8,226–9,867) | 0.630a |
| Yes | 10 (4.3) | 7,612 (4,154–13,944) | 17 (7.2) | 9,797 (6,914–13,880) | |||
| Itching | No | 228 (97.0) | 9,061 (8,291–9904) | 0.966a | 224 (95.3) | 9,122 (8,333–9,984) | 0.437a |
| Yes | 7 (3.0) | 9,166 (4,192–17,108) | 11 (4.7) | 7,974 (5,573–11,408) | |||
| Systemic Reactions | |||||||
| Fever | <37.0 °C | 218 (92.8) | 9,137 (8,356–9,990) | 0.290b | 93 (39.6) | 7,186 (6,314–8,180) | <0.001b |
| 37.0–37.9 °C | 15 (6.4) | 8,927 (5,617–14,188) | 91 (38.7) | 9,374 (8,152–10,781) | |||
| ≥38 °C | 2 (0.9) | 4,276 (597–30,620) | 51 (21.7) | 13,035 (10,943–15,528) | |||
| Fatigue | No | 205 (87.2) | 8,972 (8,190–9,829) | 0.603a | 108 (46.0) | 7,947 (6,992–9,030) | 0.006a |
| Yes | 30 (12.8) | 9,723 (7,211–13,111) | 127 (54.0) | 10,139 (9,014–11,402) | |||
| Headache | No | 215 (91.5) | 8,920 (8,145–9,772) | 0.260a | 153 (65.1) | 8,404 (7,523–9,386) | 0.017a |
| Yes | 20 (8.5) | 10,750 (7,781–14,853) | 82 (34.9) | 10,440 (9,082–12,001) | |||
| Chills | No | 229 (97.5) | 9,126 (8,366–9,959) | 0.557a | 159 (67.7) | 8,045 (7,229–8,952) | <0.001a |
| Yes | 6 (2.6) | 6,964 (2,313–20,970) | 76 (32.3) | 11,633 (10,127–13,366) | |||
| Nausea | No | 230 (97.9) | 9,061 (8,295–9,899) | 0.963a | 217 (92.3) | 8,925 (8,147–9,777) | 0.218a |
| Yes | 5 (2.1) | 9,204 (3,796–22,325) | 18 (7.7) | 10,922 (7,930–15,038) | |||
| Diarrhea | No | 229 (97.5) | 9,020 (8,255–9,854) | 0.536a | 220 (93.6) | 9,059(8,274–9,922) | 0.964a |
| Yes | 6 (2.6) | 10,967 (5,178–23,233) | 15 (6.4) | 9,131 (6,396–13,038) | |||
| Muscle Pain | No | 188 (80.0) | 8,847 (8,000–9,784) | 0.229a | 168 (71.5) | 8,668 (7,805–9,625) | 0.103a |
| Yes | 47 (20.0) | 9,988 (8,398–11,877) | 67 (28.5) | 10,141 (8,654–11,865) | |||
| Joint Pain | No | 223 (94.9) | 9,166 (8,397–10,007) | 0.430a | 176 (74.9) | 8,720 (7,872–9,661) | 0.122a |
| Yes | 12 (5.1) | 7,364 (4,117–13,170) | 59 (25.1) | 10,174 (8,596–12,041) | |||
| Rash | No | 231 (98.3) | 9,152 (8,379–9,995) | 0.011a | 231 (98.3) | 9,074 (8,306–9,911) | 0.875a |
| Yes | 4 (1.7) | 5,207 (3,582–7,570) | 4 (1.7) | 8,549 (2,842–25,704) | |||
a: t-test.
b: ANOVA.
GMT, geometric mean titer.