Table 3.
Effect of antipyretic use on IgG(S-RBD) titer.
| No. (%) | GMT (95 %CI) | p-value | |||
|---|---|---|---|---|---|
| Use of Antipyretics | No | 182 (54.3) | 8,304 (7,502–9,193) | 0.083a | |
| Yes | 153 (45.7) | 9,458 (8,501–10,524) | |||
| Antipyretic Type | Only Acetaminophen | 70 (45.8) | 8,955 (7,634–10,506) | 0.785b | |
| Only Loxoprofen | 43 (28.1) | 9,585 (7,745–11,861) | |||
| Both | 13 (8.5) | 10,216 (7,093–14,714) | |||
| Others† | 27 (17.7) | 10,584 (8,122–13,794) | |||
| Duration between Vaccination and Subsequent Use of Antipyretics ‡ | After Dose 1 | ≤6 hrs | 18 (43.9) | 9,005 (7,003–11,578) | 0.598b |
| 7–24 hrs | 21 (51.2) | 7,294 (5,250–10,135) | |||
| ≥25 hrs | 2 (4.9) | 6,905 (N/A) | |||
| After Dose 2 | ≤6 hrs | 33 (23.7) | 8,822 (7,140–10,900) | 0.480b | |
| 7–24 hrs | 91 (65.5) | 10,286 (8,977–11,786) | |||
| ≥25 hrs | 15 (10.8) | 9,254 (6,094–14,051) | |||
| Timing of Using Antipyretics | Only After Dose 1 | 9 (5.9) | 5,769 (3,089–10,770) | 0.046b | |
| Only After Dose 2 | 111 (72.6) | 10,038 (8,861–11,373) | |||
| After Both Doses | 33 (21.6) | 8,862 (7,168–10,958) | |||
N/A, not available.
a: t-test
b: ANOVA.
† Antipyretics, including over-the-counter drugs, such as ibuprofen, acetylsalicylic acid, meloxicam, and drugs combining acetaminophen and an Non-Steroidal Anti-Inflammatory Drug (with or without acetaminophen and/or loxoprofen).
‡ The interval between each vaccination and the subsequent use of antipyretics was not available for one participant after the first dose and for five after the second dose.
GMT, geometric mean titer.