Table 1.
Functional implications of mutations in SARS‐CoV‐2 Delta variant.
| Mutation | Functional domain/region | Is solvent accessible? | Functional implications |
|---|---|---|---|
| Spike E156G | N‐terminal domain | Yes | Antibody escape (Chi et al, 2020; preprint: Venkatakrishnan et al, 2021) |
| Spike ΔF157 | |||
| Spike ΔR158 | |||
| Spike L452R | Receptor‐binding domain | Yes | Antibody escape (Li et al, 2020b; Liu et al, 2021b) |
| Spike T478K | |||
| Spike D614G | – | Yes | Increases spike density and infectivity of virion (Zhang et al, 2020), and viral replication (Plante et al, 2021) |
| Spike P681R | – | Yes | Increased transmissibility (preprint: Cherian et al; Scudellari, 2021) |
| M I82T | Membrane‐spanning helix (TM3)(Shen et al, 2021) | Yes | More biologically fit, with altered glucose uptake during viral replication (Shen et al, 2021) |
| NSP12 P323L | – | Yes | Increased transmissibility (preprint: Wang et al, 2020) |
Mutations in the SARS‐CoV‐2 Delta variant with known functional implications.