TABLE 1.
Ceruloplasmin diagnostic accuracy (sensitivity, specificity, PPV, and NPV using 95% CI)
| Author (Year) | Threshold | Sensitivity vs. Specificity (95% CI) | PPV vs. NPV (95% CI) |
|---|---|---|---|
| Mak et al. (2008) 15 | 0.1 g/L | 78.9% (CI: 66.1–88.6) vs. 100% (CI: 97.3–100) | 100% (CI: NE) vs. 91.9% (CI: 87.3–94.9) |
| Nicastro et al. (2010) 11 | 0.1 g/L | 65% (CI: 66.1–88.6) vs. 96.6% (CI: 88.1–99.6) | 92.9% (CI: 76.6–98.1) vs. 80% (CI: 72.3–86) |
| Sezer et al. (2014) 12 | 0.2 g/L | 77.1% (CI: 59.9–89.6) vs. 65.9% (CI: 49.4–79.9) | 65.9% (CI: 54.9–75.4) vs. 77.1% (CI: 63.9–86.6) |
| Xu et al. (2018) 13 | 0.2 g/L | 99% (CI: 97.1–99.8) vs. 80.9% (CI: 79.6–82.2) | 29.1% (CI: 27.8–30.5) vs. 99.9% (CI: 99.7–100) |
| Merle et al. (2009) 14 | 0.19 g/L | 93.6% (CI: 87.3–97.4) vs. 58.8% (CI: 44.2–72.4) | 83.1% (CI: 77.9–87.2) vs. 81% (CI: 66.9–90.1) |
Abbreviations: CI, confidence interval; NE, not estimated; NPV, negative predictive value; PPV, positive predictive value.