TABLE 3.
Hepatic copper test diagnostic accuracy (sensitivity, specificity, PPV, and NPV using 95% CI)
| Author (Year) | Threshold | Sensitivity vs. Specificity (95% CI) | PPV vs. NPV (95% CI) |
|---|---|---|---|
| Ferenci et al. (2005) 17 | >4 μmol/g | 88.3% (CI: 75.2–89.7) vs. 98.6% (CI: 96.1–99.7) | 96.9% (CI: 91.1–99) vs. 91.9% (CI: 88.3–94.5) |
| Ferenci et al. (2005a) 17 | >1.2 μmol/g | 96.5% (CI: 91.3–99) vs. 95.4% (CI: 91.8–97.8) | 91.7% (CI: 85.7–95.3) vs. 98.1% (CI: 95.2–99.3) |
| Nicastro et al. (2010) 11 | >4 μmol/g | 93.3% (CI = 77.9–99.2) vs. 52.2% (CI = 37–67.1) | 56% (CI: 48.1–63.6) vs. 92.3% (CI: 75.4–97.9) |
| Sezer et al. (2014) 12 | >4 μmol/g | 65.7% (CI = 47.8–80.9) vs. 75.6% (CI = 59.7–87.6) | 69.7% (CI: 56.1–80.6) vs. 72.1% (CI: 61.3–80.8) |
| Yang et al. (2015) 18 | >4 μmol/g | 94.4% (CI = 89.9–97.3) vs. 96.8% (CI = 94.7–98.2) | 91.8% (CI: 87.2–94.9) vs. 97.8% (CI: 96.1–97.5) |
Abbreviations: CI, confidence interval; NPV, negative predictive value; PPV, positive predictive value.