Table 3.

Univariate and multivariate analyses of the factors influencing OS and RFS with a Cox proportional hazard model.

Parameters	RFS				OS
	Univariate analysis		Multivariate analysis		Univariate analysis		Multivariate analysis
	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value	HR (95% CI)	p value
Age (year)
>60 versus ⩽60	0.879 (0.519–1.486)	0.629			1.046 (0.523–2.090)	0.899
Gender
Male versus Female	1.175 (0.695–1.987)	0.548			0.837 (0.425–1.649)	0.607
Primary tumor location
Rectum versus Colon	1.449 (0.871–2.411)	0.154			1.611 (0.822–3.158)	0.165
Primary tumor size (cm)
> 4.0 versus ⩽4.0	0.606 (0.364–1.008)	0.053			0.595 (0.302–1.171)	0.133
Primary tumor differentiation
Well/moderate versus Poor	1.292 (0.736–2.269)	0.372			0.695 (0.287–1.681)	0.419
T category
4 versus 1–3	1.609 (0.928–2.789)	0.090			1.592 (0.753–3.364)	0.223
N category
1–2 versus 0	2.205 (1.213–4.007)	0.009	2.235 (1.229–4.064)	0.008	2.165 (0.961–4.874)	0.062
Liver metastases tumor size (cm)
> 2.5 versus ⩽2.5	1.294 (0.778–2.153)	0.321			1.279 (0.651–2.511)	0.475
Hepatic resection timing
Metachronous versus Synchronous	0.859 (0.514–1.436)	0.562			0.626 (0.310–1.266)	0.193
Preoperative CEA (ng/ml)
>5 versus ⩽5	1.143 (0.644–2.026)	0.648			1.049 (0.489–2.250)	0.901
Preoperative CA19-9 (U/ml)
>35 versus ⩽35	0.921 (0.555–1.530)	0.751			1.165 (0.592–2.296)	0.658
Perioperative chemotherapy
Yes versus No	0.629 (0.334–1.185)	0.152			0.821 (0.357–1.890)	0.643
TROP2 expression of liver metastasis
High versus Low	2.017 (1.198–3.396)	0.008	1.877 (1.091–3.230)	0.023	2.090 (1.037–4.214)	0.039	2.090 (1.037–4.214)	0.039

CA19-9, carbohydrate antigen 19-9 before liver tumor resection; CEA, carcinoembryonic antigen before liver tumor resection; CI, confidence interval; HR, hazard ratio; OS, overall survival; RFS, recurrence-free survival; TROP2, trophoblast antigen protein 2.