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Differential metabolites and metabolic pathways from vitreous. (A) Volcano plot analysis for detecting significantly changed metabolites. Upregulated and downregulated metabolites are in red and blue, respectively. Nonsignificant metabolites are represented by gray dots. (B) Metabolite set enrichment analysis of all discriminating metabolites was performed and top 25 differential pathways were displayed. (C) Heatmap showing relative peak areas of dysregulated metabolites in vitreous.
