Figure 4. Restricting average controllability to direct structural connections increases redundancy with strength and reduces prediction performance in transmodal cortex.

Columns represent average controllability recalculated using different values of the c parameter from Eq. 3; greater values of c correspond to greater restriction of average controllability’s capacity to access indirect connections (see Supplementary Materials and Figure S3 for details). A, The cross-subject correlation between strength (str) and average controllability (ac) as a function of the principal cortical gradient. Increases in c resulted in increases to the cross-subject correlations (y-axes) and a reduction in the spatial correlations with the cortical gradient, wherein correlations in transmodal cortex became increasingly redundant. B, Performance for the binned-regions prediction model for average controllability predicting positive psychosis spectrum symptoms. The spatial correlation between prediction performance and the cortical gradient diminished with increasing c, yielding lower prediction performance in transmodal cortex.