Table 1.
Participant Characteristics by Disease Type and Stage
| HD Disease Type | HD Disease Stage | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-HD Controls (N = 4,958) |
All HD (N = 14,791) |
CAG 36–39 (N = 833) |
CAG 40–59 (N = 13,862) |
CAG ≥ 60 (N = 96) |
Premanifest (N = 5,612) |
Early Stage (N = 6,696) |
Mid Stage (N = 1,911) |
Late Stage (N = 572) |
|
| Sleep Disturbance Prevalence | 277 (5.6) | 2312 (15.6) | 119 (14.3) | 2166 (15.6) | 27 (28.1) | 472 (8.4) | 1124 (16.8) | 516 (27.0) | 200 (35.0) |
| Age (y) | 46.6 (14.8) | 48.2 (13.9) | 55.1 (15.3) | 47.9 (13.6) | 24.6 (4.2) | 40.5 (12.4) | 51.9 (12.3) | 54.8 (13.0) | 56.6 (13.4) |
| Sex (F) | 3006 (61.1) | 7994 (54.0) | 468 (56.2) | 7476 (53.9) | 50 (52.1) | 3318 (59.1) | 3310 (49.4) | 1034 (54.1) | 332 (58.0) |
| History of Alcohol Use (%) | 2761 (56.2) | 7696 (52.0) | 512 (61.5) | 7163 (51.7) | 21 (21.9) | 3524 (62.8) | 3348 (50.0) | 706 (36.9) | 118 (20.6) |
| History of Tobacco Use (%) | 2126 (43.2) | 7090 (47.9) | 379 (45.5) | 6672 (48.1) | 39 (40.6) | 2534 (45.2) | 3344 (49.9) | 936 (49.0) | 276 (48.3) |
| Depression Subscore | 3.4 (5.1) | 5.0 (6.3) | 3.9 (5.6) | 5.0 (6.3) | 3.9 (5.2) | 4.6 (6.1) | 5.2 (6.2) | 5.4 (6.8) | 5.4 (6.3) |
| Psychosis Subscore | 0.1 (0.7) | 0.3 (1.5) | 0.1 (0.5) | 0.3 (1.6) | 0.4 (1.6) | 0.1 (1.1) | 0.2 (1.4) | 0.5 (2.2) | 0.9 (3.0) |
| SDMT Score | 50.0 (12.1) | 32.2 (17.7) | 41.3 (17.3) | 31.7 (17.6) | 19.5 (11.4) | 48.0 (12.9) | 26.3 (11.2) | 14.3 (8.9) | 5.0 (6.5) |
Data are presented as mean (SD) for continuous variables and N (%) for categorical variables. The statistical difference in in sleep disturbance prevalence, sex, history of alcohol use, and history of tobacco use were determined using the chi-squared test while the one-way ANOVA test was used for all other parameters. In each comparison to the Non-HD Controls, all groups were statistically significantly different with p value < 0.001. SDMT – Symbol Digit Modality Test