Table 1.
Demographic characteristics of the study participants based on GLUT1 rs841853 genotypes (CC and CA + AA)
| rs841853-CC | rs841853-CA + AA | p-value | |
|---|---|---|---|
| (n = 735) | (n = 565) | ||
| Fasting blood glucose (mg/dL) | 92.07 ± 7.78 | 91.62 ± 7.14 | 0.278 |
| TXNIP cg19693031 (β) | 0.7716 ± 0.05 | 0.7631 ± 0.05 | 0.002 |
| TXNIP cg19693031 quartiles | 0.005 | ||
| Q3 (β ≥ 0.800918) | 210 (28.57) | 117 (20.71) | |
| Q2–Q3 (0.769992 ≤ 0.800918) | 187 (25.44) | 140 (24.78) | |
| Q1–Q2 (0.738592 ≤ 0.769992) | 168 (22.86) | 158 (27.96) | |
| Q1 (β < 0.738592) | 170 (23.13) | 150 (26.55) | |
| Sex | 0.309 | ||
| Women | 385 (52.38) | 312 (55.22) | |
| Men | 350 (47.62) | 253 (44.78) | |
| Age (years) | 48.87 ± 11.03 | 48.22 ± 11.06 | 0.288 |
| BMI (kg/m2) | 23.95 ± 3.36 | 24.31 ± 3.75 | 0.071 |
| Cigarette smoking | 0.191 | ||
| No | 559 (76.05) | 447 (79.12) | |
| Yes | 176 (23.95) | 118 (20.88) | |
| Alcohol drinking | 0.889 | ||
| No | 667 (90.75) | 514 (90.97) | |
| Yes | 68 (9.25) | 51 (9.03) | |
| Triglyceride (mg/dL) | 112.56 ± 95.94 | 112.60 ± 103.11 | 0.994 |
| HDL-C (mg/dL) | 55.96 ± 14.27 | 54.42 ± 13.70 | 0.051 |
| LDL-C (mg/dL) | 122.67 ± 32.36 | 123.38 ± 33.55 | 0.699 |
| Hypertension | 0.294 | ||
| No | 603 (82.04) | 476 (84.25) | |
| Yes | 132 (17.96) | 89 (15.75) | |
| Regular exercise | 0.709 | ||
| No | 420 (57.14) | 317 (56.11) | |
| Yes | 315 (42.86) | 248 (43.89) | |
| Tea intake | 0.460 | ||
| No | 451 (61.36) | 358 (63.36) | |
| Yes | 284 (38.64) | 207 (36.64) | |
| Coffee intake | 0.997 | ||
| No | 471 (64.08) | 362 (64.07) | |
| Yes | 264 (35.92) | 203 (35.93) | |
| Vegetarian diet | 0.405 | ||
| No | 671 (91.29) | 588 (92.57) | |
| Yes | 64 (8.71) | 49 (7.43) |
Minimum and maximum TXNIP cg19693031 β = 0.510186 and 0.918557, respectively
Continuous variables are represented by mean ± SD and categorical variables by n (%)
GLUT1 glucose transporter 1, SD standard deviation, β beta-value, TXNIP thioredoxin-interacting protein, BMI body mass index, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol