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. 2022 Feb 14;10:22. doi: 10.1186/s40478-022-01322-x

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The poly-GA associated proteome is distinct from those for poly-GR and -PR. A Venn Diagram showing the overlap between the identified associated proteins for poly-GA, poly-GR and poly-PR dipeptide repeats; B Heatmap of the most enriched GO and KEGG terms in DPR-associated protein sets. Cell colors represent − log10 of the adjusted p-value of enrichment; C STRING interaction network for a subset of the identified poly-GA associated proteins that belong to the indicated GO or KEGG terms or directly interact with proteins belonging to these terms. Node colors indicate protein affiliation with the indicated terms. Solid edges represent the interactions from the STRING database, transparent edges illustrate the association between poly-GA and proteins shown here. Edge thickness corresponds to the STRING combined score of an interaction. D STRING interaction network for a subset of the identified poly-GR and poly-PR associated proteins that belong to the indicated GO or KEGG terms or directly interact with proteins belonging to these terms. Node colors indicate protein affiliation with the indicated terms. Transparent edges represent the interactions from the STRING database, solid edges illustrate the association between poly-GR or poly-PR and proteins shown here