Table 2.
Primary and secondary outcomes
| Total (n = 124) | Lopinavir/Ritonavir (n = 62) | Atazanavir/Ritonavir (n = 62) | P -value | |
| Primary outcomes | ||||
| Discharge during 10 days, n (%) | 96 (72.7) | 41 (66.1) | 51 (82.3) | 0.06 |
| Number of days taking study medication, median (IQR25-75) | 7 (5-9) | 7 (6-9) | 6 (5-8) | 0.01 |
| Final outcome | ||||
| Discharge, n (%) | 92 (74.2) | 41 (66.1) | 51 (82.3) | 0.03 |
| Death, n (%) | 2 (1.6) | 2 (3.2) | 0 (0) | |
| Withdrawal of consent, n (%) | 2 (1.6) | 0 (0) | 2 (3.2) | |
| Release sheet, n (%) | 28 (22.6) | 19 (30.6) | 9 (14.5) | |
| Final respiratory rate (/min), median (IQR25-75) | 19 (18-20) | 20 (18-22) | 18 (18-20) | 0.02 |
| Final Arterial O2 saturation (%), median (IQR25-75) | 96 (94-97) | 96 (91-97) | 97 (95-98) | 0.04 |
| Secondary outcomes | ||||
| Discharge during 14 days, n (%) | 102 (82.3) | 47 (75.8) | 55 (88.7) | 0.09 |
| ICU Admission, n (%) | 6 (4.8) | 3 (4.8) | 3 (4.8) | ≥0.99 |
| Intubation, n (%) | 3 (2.4) | 2 (3.2) | 1 (1.6) | ≥0.99 |
| Mortality Rate, n (%) | 2 (1.6) | 2 (3) | 0 (0) | 0.49 |
| Number of days stay in ICU, (max-min) | 5 | 4 | 5 | 0.98 |
| Number of days intubated, (max-min) | 4 | 4 | 3 | 0.57 |
| Laboratory tests on day 3, median (IQR 25-75 ) | ||||
| CRP | 3 (1-3) | 3 (1.2-3) | 3 (1-3) | 0.83 |
| WBC (×109/L) | 6 (4.8-8.2) | 5.9 (4.7-7.7) | 6.2 (4.8-8.3 | 0.62 |
| PMN (%) | 75.4 (64.2-83.1) | 75 (62.3-81.4) | 75.9 (66.3-84.2) | 0.39 |
| Lymphocyte (×109/L) | 1.2 (0.9-1.5) | 1.2 (0.9-1.5) | 1.1 (0.9-1.4) | 0.30 |
| Bilirubin total | 0.7 (0.6-1.2) | 1.1 (0.7-1.7) | 0.6 (0.6-0.7) | ≤0.001 |
| Bilirubin direct | 0.4 (0.3-0.7) | 0.6 (0.4-0.9) | 0.3 (0.3-0.4) | ≤0.001 |
| Laboratory tests on day 7, median (IQR 25-75 ) | ||||
| CRP | 1 (0-3) | 1 (0-3) | 2 (0-3) | 0.69 |
| WBC (×109/L) | 8.5 (5.2-11.2) | 8.5 (4.4-11.1) | 8.4 (5.5-13.8) | 0.47 |
| PMN (%) | 78.5 (69-85.8) | 74.3 (68.4-90.5) | 79.7 (69-87.7) | 0.84 |
| Lymphocyte (×109/L) | 1 (0.7-1.3) | 0.9 (0.8-1.4) | 1 (0.7-1.3) | ≥0.99 |
| Bilirubin total | 0.8 (0.6-1.2) | 1.3 (0.9-1.7) | 0.7 (0.6-0.7) | ≤0.001 |
| Bilirubin direct | 0.4 (0.3-0.7) | 0.7 (0.4-0.9) | 0.3 (0.3-0.4) | ≤0.001 |
| PCR day 7, n (%) | ||||
| Positive | 13 (16.9) | 8 (17.2) | 5 (16.7) | ≥0.99 |
| Negative | 27 (35.1) | 17 (36.2) | 10 (33.3) | |
| Not done | 37 (48) | 22 (46.8) | 15 (50) | |
| PCR day 14, n (%) | ||||
| Positive | 3 (23.1) | 1 (12.5) | 2 (40) | 0.50 |
| Negative | 7 (53.8) | 5 (62.5) | 2 (40) | |
| Not done | 3 (23.1) | 2 (25) | 1 (20) | |
CRP: C-reactive protein; WBC: white blood cell; PMN: polymorphonuclear; PCR: polymerase chain reaction.