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Independent and dependent parameters employed in D-optimal design for preparation and optimization of imatinib-TFS
| Variables | Levels | ||
|---|---|---|---|
| X1 = Lecithin content (mg) | 25 | 37.5 | 50 |
| X2 = Lecithin/EA ratio (w/w) | 4 | 7 | 10 |
| X3 = EA Type | Span20 | Span80 | Tween80 |
| Dependent variables | Constraints | ||
| Particle size (nm) | Minimize | ||
| PDI | Minimize | ||
| Zeta potential (mv) | Minimize | ||
| Encapsulation efficiency% | Minimize | ||
| Release efficiency during 24 h | Minimize | ||
