Table 4.

Physicochemical properties of imatinib-TFS after freeze-drying with and without cryoprotectants

Cryoprotectants	Concentration%, (w/v)	Particle size, (nm)	PDI	Dispersion time, (s)
-	-	846.13 ± 12.84	0.658 ± 0.019	55.33 ± 2.62
Sucrose	1	235.37 ± 2.9	0.524 ± 0.003	28.33 ± 2.49
	3	173.63 ± 3.4	0.472 ± 0.003	21.00 ± 1.63
Mannitol	1	783.67 ± 5.5	0.286 ± 0.002	60.33 ± 6.60
	3	862.33 ± 72	0.310 ± 0.002	42.67 ± 2.49
Lactose	1	357.97 ± 7.6	0.328 ± 0.003	57.67 ± 6.80
	3	248.50 ± 5.3	0.815 ± 0.044	45.67 ± 4.03