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. 2022 Jan 31;13:787021. doi: 10.3389/fimmu.2022.787021

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Copyright © 2022 Adamek, Matras, Rebl, Stachnik, Falco, Bauer, Miebach, Teitge, Jung-Schroers, Abdullah, Krebs, Schröder, Fuchs, Reichert and Steinhagen

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mortality and virus load after the vaccination with KHV-T ΔDUT/TK. (A) Approximated mortality during vaccination. (B) Virus load in the skin collected 2 days post vaccination (dpv), 7 dpv, 14 dpv, 28 dpv. (C) Virus load in the gills. (D) Virus load in the kidney. The description of experimental groups: B – BSA non-vaccinated, D – defensins non-vaccinated, VB - BSA vaccinated, VD – defensins vaccinated. The results are presented as 25%-75% box plots with min. and max. values as whiskers with indication of all data points. The data are shown as virus genome copy per 250 ng of extracted DNA. * indicates statistical significant difference to non-vaccinated controls at p < 0.05. Statistical analysis was performed with two-way ANOVA with multiple comparisons test performed with the Holm-Sidak method.